During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Use Caution/Monitor. Minor/Significance Unknown. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Applies only to oral form of both agents. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Applies only to oral form of both agents. Applies only to oral form of both agents. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of Venofer is expressed in mg of elemental iron. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. This site contains information for licensed healthcare professionals in the United States. Please confirm that you would like to log out of Medscape. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Ferric gluconate: 12.5 mg/mL. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Suggested regime: Prescribing instructions Prescribing a single/first dose: Minor/Significance Unknown. Avoid or Use Alternate Drug. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Avoid or Use Alternate Drug. Am J HealthSyst Pharm 2006;63:731735. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Included in the iron dextran package insert. 2010;18(3). iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Do not double the dose to catch up. Applies only to oral form of both agents. Fatal reactions have followed the test dose of iron dextran injection. https://www.uptodate.com/ (Requires subscription). Minor/Significance Unknown. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). 3. Applies only to oral form of both agents. May increase risk of hypotension. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Canada residents can call a provincial poison control center. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Avoid or Use Alternate Drug. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Kumpf VJ, Holland EG. Deferoxamine chelates iron. Separate dosing of tetracyclines from these products. The dosage of Venofer is expressed in mg of elemental iron. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Applies only to oral form of both agents. Medically reviewed by Drugs.com. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Volume of iron product required = 25 mL. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Intravenous iron sucrose: establishing a safe dose. Monitor Closely (1)trientine, iron sucrose. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Use Caution/Monitor. . Applies only to oral form of both agents. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Schweiz Med Wochenschr. Avoid or Use Alternate Drug. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. LBW = Lean body weight in kg. Use Caution/Monitor. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Fatal reactions have also occurred in situations where the test dose was tolerated. Separate by 2 hr. Maximum recommended single dose: 300 mg (See Prescriber's Orders). US residents can call their local poison control center at 1-800-222-1222. Modify Therapy/Monitor Closely. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Deferoxamine chelates iron. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. It is unlikely . Do not administer Venofer to patients with evidence of iron overload. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. The elemental iron product used is Iron sucrose 20 mg/mL. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Drug Des Devel Ther; 5: 5160. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Use Caution/Monitor. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Venofer treatment may be repeated if iron deficiency reoccurs. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. No additional iron to replenish stores. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Applies only to oral form of both agents. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . 1000 mg. 20 MINUTES. David McAuley, Pharm.D. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Kumpf VJ. Assessing new treatment options. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. [. Interaction only with oral iron administration. . Applies only to oral form of both agents. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Applies only to oral form of both agents. J Lab Clin Med; 111(5):566-70. Do Not Copy, Distribute or otherwise Disseminate without express permission. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Either increases effects of the other by pharmacodynamic synergism. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. J Med. . For liquid medications, also enter the value of the Medicine Concentration and choose . iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Formula for calculating the required dose of iron sucrose 1. Use Caution/Monitor. Separate dosing of tetracyclines from these products. This product may contain inactive ingredients, which can cause allergic reactions or other problems. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course.